Oral delivery of maize-produced porcine epidemic diarrhea virus spike protein elicits neutralizing antibodies in pigs
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چکیده
منابع مشابه
Porcine Epidemic Diarrhea Virus among Farmed Pigs, Ukraine
An outbreak of porcine epidemic diarrhea occurred in the summer of 2014 in Ukraine, severely affecting piglets <10 days of age; the mortality rate approached 100%. Full genome sequencing showed the virus to be closely related to strains reported from North America, showing a sequence identity of up to 99.8%.
متن کاملImmunogenicity of a recombinant parapoxvirus expressing the spike protein of Porcine epidemic diarrhea virus.
The parapoxvirus Orf virus (ORFV), has long been recognized for its immunomodulatory properties in permissive and non-permissive animal species. Here, a new recombinant ORFV expressing the full-length spike (S) protein of Porcine epidemic diarrhea virus (PEDV) was generated and its immunogenicity and protective efficacy were evaluated in pigs. The PEDV S was inserted into the ORFV121 gene locus...
متن کاملDetection and Molecular Diversity of Spike Gene of Porcine Epidemic Diarrhea Virus in China
Since late 2010, porcine epidemic diarrhea virus (PEDV) has rapidly disseminated all over the China and caused considerable morbidity and high mortality (up to 100%) in neonatal piglets. 79.66% (141 of 177) pig farms in 29 provinces (excluding Tibet and Hainan, China) and 72.27% (417 of 577) samples were positive for PEDV confirmed by reverse transcription-polymerase chain reaction (RT-PCR). Th...
متن کاملImpact of Porcine Epidemic Diarrhea on Performance of Growing Pigs
The impact of porcine epidemic diarrhea virus (PEDv) infection on the US pork industry has mainly been attributed to the mortality that it causes in suckling piglets, and, consequently, much effort has been invested in the quantification of its effect in sow farms. However, no information on the performance of surviving pigs that were exposed to the PEDv as piglets is available. Here, a retrosp...
متن کاملFecal shedding of a highly cell-culture-adapted porcine epidemic diarrhea virus after oral inoculation in pigs
Received: October 28, 2004 Accepted: January 26, 2005 Porcine epidemic diarrhea virus (PEDV), an enveloped, singlestranded RNA virus1,2 in the family Coronaviridae, causes severe diarrhea in swine. The main and only obvious clinical sign of porcine epidemic diarrhea (PED) is watery diarrhea. Mortality may be as high as 80%, but averages 50%.3,4 Piglets up to 1 week of age may die from dehydrati...
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ژورنال
عنوان ژورنال: Plant Cell, Tissue and Organ Culture (PCTOC)
سال: 2020
ISSN: 0167-6857,1573-5044
DOI: 10.1007/s11240-020-01835-0